DoctorX pills: "Ketamine harm reduction" : HarmReduction | Torhoo darknet markets

1.- General aspects

Ketamine is a dissociative anesthetic that was first synthesized in 1962 and has since been widely used in both animals and humans. Its medical use is limited by the psychedelic side effects that appear in the recovery phase. Nevertheless, it is still an anesthetic used in pediatrics, geriatrics, obstetrics, and as an analgesic in pain management units. Additionally, it is one of the most widely used anesthetics in the world, especially in low- and middle-income countries and in emergencies due to disasters.

Ketamine (2-chlorophenyl-2-methylamine-cyclohexanone) is structurally related to phencyclidine and its analgesic and dissociative effects are produced by its antagonistic action on glutamatergic receptors (NMDA).

It expires between one and five years after its manufacture. It should be kept away from sunlight and preferably at a temperature between 4 and 25 degrees Celsius.

2.- Dosage

• Oral route:
• • Low dose: 50-100 milligrams.
  • Medium-high dose: 75-300 milligrams.
• Nasal route (snorted):
• • Low dose: 15-30 milligrams.
  • Medium dose: 30-75 milligrams.
  • High dose: starting from 75 milligrams.
• Intramuscular route:
• • Low dose: 15-30 mg
  • Medium dose: 25-50 mg
  • High dose: around 100 mg

Duration: Around 1-2 hours.

3.- Common Adverse Effects

Ketamine is an anesthetic, so too high or too frequent doses can cause significant bodily impairment (loss of balance, reflexes, etc.) that can pose a significant risk of falls and accidents. To avoid this, it will be necessary to take care of the dosage and space out the doses sufficiently.

At the time of consumption, along with the desired effects, one may experience nausea, vomiting, dizziness, vertigo, sweating, headaches, confusion, and disorientation. It decreases the ability to pay attention, concentrate, and remember, and amnesia may occur. The day after, the person may feel somewhat tired, dizzy, and with a heavy head.

4.- Toxic/Severe/Rare Effects

Continued use promotes the development of tolerance and dependence. Although withdrawal syndrome has not been described, some people develop compulsive consumption patterns similar to those of cocaine.

Physical (abdominal pain, eye problems, tremors, etc.) and psychological (anxiety, insomnia, psychosis, etc.) disorders may also appear.

Chronic use can damage the bladder and urinary system. The first symptoms (burning sensation when urinating, urgency, or blood in the urine) are usually reversible with complete abstinence. If consumption continues, the condition becomes chronic and progressive, leading to bladder destruction. The intranasal route and the use of large quantities or very frequent frequencies are associated with this problem. Daily consumption has a high risk and rarely appears in occasional consumption.

The psychedelic effects of ketamine are qualitatively distinct from those of LSD or mushrooms and have to do with the perception of one's own body. Occasionally, it is possible to reach a catatonic state in which the body can be seen from the outside or to develop Near-Death Experiences (NDEs): the sensation of leaving one's own body, passing through a tunnel, and merging into an eternity without time or space. This experience can be a "desired effect" (if sought by a trained psychonaut in an appropriate context) or a "psychological trauma" (if it occurs in a recreational environment and the person is not warned). Some people have difficulty integrating and making sense of this type of experience.

5.- Interaction with Other Drugs and Medications

5.1.- With substances such as alcohol, GHB, or opioids

It leads to a potentiation of depressive effects (loss of coordination, sedation, fainting, etc.). In terms of safety, this is a discouraged combination, and if done, it is advisable to reduce doses and space out the doses.

5.2. With stimulants (cocaine or amphetamine/speed)

Stimulants counteract the effects of ketamine, making it counterproductive for psychonautic uses. For recreational uses, it is important to keep in mind that the risk of falls and accidents is still present. The fact that the effects of both substances counteract each other can lead to higher consumption of each substance, promoting the development of tolerance and addiction in people who use them regularly.

5.3. With psychedelics

For some people, combining ketamine with psychedelics can add interesting nuances to the experience. However, it involves mixing substances with very intense effects, so in case of combination, it is important to follow the usual recommendations for the consumption of psychedelics: basically, do it in a safe context and in a good emotional state, take care of the doses, and avoid doing it regularly.

6.- Harm Reduction

6.1. Be careful with the amount you are going to take

Taking too much ketamine can make the psychedelic effects too intense and/or not suitable for the place where you consume it (e.g., a party). This can happen if you leave little time between lines, if you take them too big, or if you are very sensitive to the effects, so you will need less quantity than other people.

6.2.-Start with a test dose to assess and decide what your pace will be.

The lines should be smaller than those used normally with other snorting substances.
Leave a reasonable amount of time between lines. Wait for the effects to subside a bit before taking more.
Decide how far you want to go. Set your own limit.
Stop taking it if you feel more negative effects than positive ones.
Decide how much you are going to take each time. Nobody forces you to take everything they put in front of you. Set your own pace.

6.3. Consume with company

Inform your companions in advance that you are going to take ketamine. This will facilitate an adequate response in case of an adverse reaction.

6.3.- Take care of your nose

Sniffing can cause lesions in the nasal passages such as sinusitis (inflammation of the mucosa covering the sinuses), rhinitis (inflammation of the mucosa of the nasal passages), nosebleeds and, in the case of continued use, ulcerations and perforations of the nasal septum. In addition, some studies suggest that sharing the sniffing strip may be a risk factor for the transmission of Hepatitis C virus.

Spray the ketamine you are going to take well, avoiding leaving large particles or crystals that could injure your nostrils.

Use a clean surface (never on a toilet bowl, for example).

Avoid using banknotes or other unhygienic materials.

Clean your nostrils thoroughly before and after sniffing (with lukewarm water) to remove debris.


Use a clean, disposable sniffing strip of your own. This last tip is particularly important. Hepatitis C virus (HCV) has been detected in banknotes and other materials used for snorting. There is no clear evidence that it can be transmitted by sharing turkeys but it is clear that some pathogens are transmitted by nasal fluids (e.g. common cold or flu viruses) so using one's own stuff for sniffing should be a basic hygiene rule.

6.4 Avoid taking too much too often
Most people who take ketamine do so occasionally. However, there are some who will develop problematic ketamine use.

6.5.-Space your intake.
If you notice that you need to take more than you did before, consider taking a break.

6.6.- Analyse the substance beforehand.
Be aware that sometimes ketamine may be cut or you may be sold another substance instead of ketamine. The purity of ketamine varies, so it usually has additives to give it volume. Among the most common cuts are those that have no effect (they are diluents) or those that do. Of the latter, the most common is caffeine.

Be concerned about the quality of the ketamine you are taking. Try to get as much information as possible.
Remember that there is nothing about the physical appearance of drugs that is indicative of quality: not the colour, taste, shape, etc.

Be wary of unknown material, of dubious origin or of poor quality.

Derivatives such as methoxetamine (MXE), deschloroketamine (DCK) carry much higher potential risks as they have not been studied in humans.

Morris reagent test allows to difference between ketamine and DCK, 2-FDCK, and other novel psychoactive substances.

6.7.- Ketamine use may be especially risky if you:

You suffer from heart problems, high blood pressure or have a history of stroke.

You are being treated with thyroid medication.

You have had eye surgery.

You have mental health problems such as anxiety, bipolar disorder, depression or psychotic disorders such as schizophrenia. However, supervised administration of ketamine has shown promise as a treatment for major depressive disorder.

You are pregnant, breastfeeding or thinking of becoming pregnant.

You have to drive or do any activity that, when done under the influence of ketamine, increases the risk of doing or injuring yourself.


7.- A note on ketamine isomers:

In recent years, there has been a growing interest in ketamine, and as a result, some dealers are claiming to sell special formulations of the drug, such as s-ketamine or r-ketamine "isomers". However, this is often just a marketing tactic, as r-ketamine is only produced for research purposes, and s-ketamine is only available through diversion from Johnson & Johnson's tightly controlled medical or clinical supply, which comes with great risk and expense.

Most ketamine found on the streets is actually racemic, meaning it is a mixture of both r- and s-ketamine. The only exception is ketamine that is produced for specific clinical purposes, such as those mentioned earlier, which is also tightly controlled.

Although it is possible to split racemic ketamine into r- and s-ketamine, the process is complex, time-consuming, and expensive, which means there is no incentive for dealers to do so. Unfortunately, some dealers may try to charge higher prices by claiming their product has undergone this splitting process or by telling an elaborate story about its source. It's essential to be aware of these tactics to avoid falling victim to them.


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