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Tranq (Xylazine) Reversal Agents Could Save Lives : Drugs | Torhoo darknet markets

Say what you will about fentanyl—at least naloxone (Narcan) is an effective reversal agent. Just as the FDA moves to re-classify the intranasal version as an OTC drug, another threat to the lives of those struggling with addiction is here to frustrate our efforts.

Xylaxine was developed as a veterinary anesthetic agent. However, when combined with fentanyl or other opioids, it creates profound sedation and hemodynamic instability, and death. And this cocktail isn’t reversible by Naloxone—an opioid receptor antagonist—which means not only more deaths of our fellow humans. It means more death and trauma for First Responders and to Emergency Medicine nurses, and physicians.

https://open.substack.com/pub/thefrontierpsychiatrists/p/tranq-xylazine-reversal-agents-could?r=1v91qg&utm_campaign=post&utm_medium=email

/u/plkqcs

2 points

2 years ago*

Great post. What does it take to test for this drug? I really don't want to end up like this: https://www.youtube.com/watch?v=C4gD7GAdM-U&t=14s

/u/newbieforever2018 📢 P 🐕≡≡==ヽ(ﾟεﾟヽ))

1 points

2 years ago

I don't know how to test for it. The article that I linked to was the first time that I ever heard of it.

OMG such complete and hopeless sadness in that you tube video and the perfect music to match the scenery. That looks like something that the Russians would be playing on their news channels to show their people what the WEST really looks like.

And then one of the comments below it>>>

"I'm in my mid-40s. Upon watching this I felt nothing but utter indifference. I suppose it's compassion and indignation that should have been evoked in me. I used to have both. (Among other life episodes) Poor, sad people I helped gave me cause to regret it. Such things used up every bit, every shred of philanthropy I had left. -- People, I invite you to keep to yourselves and be arbitrary with whomever and whenever you feel like it. You'll live better. I certainly do. Let God be my judge. "

/u/plkqcs

1 points

2 years ago*

I was hoping that people would just look at the image and start a discussion on tranq dope and the potential of seeing Xylazine adulterated opiates show up on the DN. Its a different supply chain, but the principle is the same. You can stretch an expensive drug with a cheap one. Its a problem because the combination is warm and euphoric,like good heroin - I probably should have picked a link to an article on tranq dope

/u/baisesk

1 points

2 years ago

Xylazine which is huge in Philly, 95% of F currently is cut with it, but it is unseen in NYC just 90 minutes away. I used to go to philly to cop because of their cheap $5 bags, but stopped around a year or 2 ago. Back then you could still find str8 F, but I did come across Xylazine cut F. It wasnt really euphoric to me, just really heavily sedating, and it wasnt the dope lean kind of sedating, more of a take a shot and wake up on the floor an hour later type sedating. Its really bad in Philly rn, people losing fingers and limbs, severe necrosis. Just saw a video of some dude trying to find a vein in his leg in the same spot where his leg was rotting away..NASTY... Can't imagine what its doing to their cardiovascular system.

/u/plkqcs

2 points

2 years ago

Thanks for this post. Totally interesting about NYC. - It is hard to get good posts by street users who often see things first. . -I don't think Xylazine adulteration will be a big problem DN, because the feed back system here is really geared to block adulterates, but opiate users need to be aware of it

/u/newbieforever2018 📢 P 🐕≡≡==ヽ(ﾟεﾟヽ))

1 points

2 years ago

" opiate users need to be aware of it"

Definitely!! One of the most recent victims>>

https://www.gofundme.com/f/selena-mascarenas

/u/bobbytrill

1 points

2 years ago

Wow that all makes a lot of sense. I definitely had xylazine cut shit from near Buffalo a couple years ago. I remember doing some and then I would wake up hours later. no nod or nothing, just out like a light. After doing it heavily for a few weeks i started having issues with limbs swelling and stiffness. Idk if that has anything to do with it. I'm not even 100% sure that the dope was cut with xylazine but it sounds like it at this point.

/u/baisesk

1 points

2 years ago

yup sounds like it, It lowers your BP like crazy and messes with your blood circulation. I did it for about 2 days and everytime I would stand up I would get crazy light headed and would almost fall over. Shit is horrible. If you wanna see the damage its causing rn in Philly check out @_kensingtonbeach on IG

/u/cthulhuskittens

1 points

2 years ago

you sure it's unseen in NYC? i have it on reasonably good authority from someone who says she encountered it last year - some kind of tranquilizer, at least, & as far as i know they aren't cutting dope with benzos (or are they?)
would love to see a xylazine testing strip, at any rate. that shit is foul

/u/baisesk

1 points

2 years ago

I mean im sure it could be, but from the people I know in Queens, Manhattan and BK, they say they haven't seen it. It even took a while for fetty to catch on over here cause alot of the og Dope heads dont like that shit. They prefer H because it has legs. I feel like that Xylazine shit is only appealing to ppl living on the streets

/u/cthulhuskittens

1 points

2 years ago

well yeah it's not appealing to anyone any more than fent originally was (except to the 'living on the street'/death wish niche market you mention) but dealers have never cut their product based on customer demand...this person theorized the dealer had added it to boost weak shit, which is why fent came into the scene as well - gives your stepped on garbage some kick. reading more about xylazine i wonder if i had some shit with that in it when i was in NYC a few years back. the timing seems off but i remember thinking it felt like it was cut with antipsychotics which are the gnarliest drugs ever that no one should ever take i don't care how bad your trip is, mental state is, just NO - & complained to the guy who insisted that the rest of his customers LOVED it, that maybe i was doing it wrong or something - which does fall in line with what the junkies in Philly who get hooked on this tranq shit experience, that they need the gnarly shit & regular dope doesn't do it for them anymore. what a disaster prohibition has been for humanity

/u/ActionC0stanza

1 points

2 years ago

its made its way to western MA thru NYC and hittin us hard right now

/u/alma44

1 points

2 years ago*

Great post Newbie , thank you.When I look on Drugs Data I have noticed that about 90% of the heroin samples now have Xylaxine in them. . A Narcan equivalent would save so many lives. Also, if there is an instant way to test for it similar to fent strips it would make a big difference, but I have not found any yet.. The side effects from this drug are horrendous.

Things just keep getting worse.America must truly hate their junkies.

/u/newbieforever2018 📢 P 🐕≡≡==ヽ(ﾟεﾟヽ))

1 points

2 years ago

Thank you. Funny because I was just having a discussion with someone and told him that here drug users are the lowest class of society.

/u/duckduckcop

1 points

2 years ago*

I don't know why this hasn't already been introduced, but it appears to me to be entirely feasible to develop a narcan equivalent that incorporates an intranasal ROI alpha-2 adrenergic antagonist, which would reverse xylazine's effects for emergency purposes.

I think they just want addicts to die. Or, they just don't think there'd be much market for it. But I kind of doubt the latter, look at the sales of narcan it has to be profitable as all fuck.

https://en.wikipedia.org/wiki/Alpha-2_adrenergic_receptor

As you can see here, Xylazine has a very high Ki, compared to all of the listed antagonists, which means that pretty much any antagonist for alpha-2 receptors is going to work. Most of the antagonists have half lives of 12 hours plus, which means they'd actually work better than narcan does quite possibly (e.g.: narcan stops being effective after about 30-90 minutes, whereas most dope will kick back in for at least a few hours after that timeframe...which is why you're supposed to take an OD victim to the hospital, in case they fall out again once the narcan wears off and the dope is still in their system)

Most of the antagonists are designed for oral use currently, so you just need to find one that can be easily aerosolized like naloxone is in the narcan kits, blend them together, put them in that same kit, and boom you've got xylazine-capable narcan.

Really shouldn't be hard. Why pharma hasn't gotten in on this, I have no idea. Mirtazapine looks promising, maybe, if it can be aerosolized easily. Yohimbine is proven to work as a Xylazine reversal agent, but only as an injection given soon after Xylazine administration, so the jury is still out on whether it could be used in a narcan-style intranasal application. Yohimbine's Ki values are lower than Mirtazapine's, but both are orders of magnitude lower than Xylazine, so in principle both are strong leads to explore.

Unfortunately, Yohimbine interacts badly with naloxone, causing a rise in blood pressure. Contraindicated. So, that won't work.

You'd want to use a higher dosage of Mirtazapine, like 50mg to 100mg, to make sure that you don't get a somnolence effect that would confuse clinical assessment of whether they're still ODing or not.

Really, the biggest challenge is finding something that doesn't interact with naloxone, which can be aerosolized for intranasal ROI with decent bioavailability. All the options I'm looking at, none of them are intranasally applied in clinical use for some reason. Which is weird, because Xylazine is, and so are a few other similar compounds to Xylazine.

Perhaps others can continue this research, and build a prototype? This can't be that difficult.

/u/alma44

1 points

2 years ago

Appreciate all the info, it is good to see that it is possible, but also can come with complications based on the way the two drugs interact, and the ROA for each..
Do you think there is anyway to iinsta test for Xylazine that is similar to fent test strips, or even a reagents test? In the past I have used a test strip for tranqs, but since Xylazine is not even approved for human use I realize that it is not included in what a basic test like that will pick up.Fent strips are so widely used now if the same could be used for Xylazine, it would be a good start,

/u/duckduckcop

1 points

1 year ago

a pharma company could theoretically make an immunoassay dip stick test for...just about anything, you know?

/u/cthulhuskittens

1 points

2 years ago

mirtazapine is absorbed quickly through the skin, or at least it comes in a formulation that can be. could be a 1-2 reversal kit with naloxone.

/u/newbieforever2018 📢 P 🐕≡≡==ヽ(ﾟεﾟヽ))

1 points

2 years ago

Thanks for the comment and mirtazapine is everywhere so it should be readily available.

/u/TheApothecari

1 points

2 years ago

"Tranq-dope" is what it's called in the US. There is ZERO fent in my area now, just this shit. I know people with bones showing thru their foot thru IV'ing xylazine. It makes these.. open wound holes that bleed pus all day.. they don't go away and eat at your flesh.. this shit is nasty. No real nod. Just being tired and passing out.. its fucked up..

/u/newbieforever2018 📢 P 🐕≡≡==ヽ(ﾟεﾟヽ))

1 points

2 years ago

Open wound holes? What a nightmare.

/u/Mandalorian

1 points

2 years ago

this shit is all over Philly right now..

/u/newbieforever2018 📢 P 🐕≡≡==ヽ(ﾟεﾟヽ))

1 points

2 years ago

Someone sent me a you tube video, looks like zombie town

/u/Mandalorian

1 points

2 years ago

haven't been that way in years, but Kensington literally looks like a scene from the Walking Dead.

watch the season of Intervention they did on that neighborhood... now imagine that x10 because they watered it down for TV

/u/newbieforever2018 📢 P 🐕≡≡==ヽ(ﾟεﾟヽ))

1 points

2 years ago

I could not believe what I was seeing when I first viewed that. I suppose that I live a very sheltered life because never have I seen anything that remotely resembled those streets.

/u/honestableton

1 points

2 years ago

Keep an eye out for the signs - keep it simple:

Xylazine is a powerful emetic for people unaccustomed to that side effect. Simply put - it's that stuff that makes you projectile vomit anything more than a sip of water.

Also:
Black discoloration
Black blisters on the skin called eschar (sp.)
Protracted withdrawal symptoms of varying severity (depends on the product, ultimately)

The real risk is the sedation that occurs unrelated to any opioid that may/may not be in the dope you're doing. It doesn't respond to Narcan, and there is a distinct withdrawal from xylazine that is much longer and much more intense than heroin or fentanyl alone - it looks like a mixture between benzo and other a2 agonists (like clonidine).

I bought approx. 14g of #4 a couple months ago on AB and it was mostly or all xylazine, then picked up tar locally and couldn't figure out what was wrong. I drained abscesses, disinfected wounds, destroyed veins, muscles, etc. It was a traumatic experience, the landscape is not the same as it was - this stuff has been around since at least 2013, but was mainly confined to PR - that changed in 2020 or so, and now Kensington in Philadelphia is basically The Last of Us.

/u/newbieforever2018 📢 P 🐕≡≡==ヽ(ﾟεﾟヽ))

1 points

2 years ago

OMG, how awful.

/u/ActionC0stanza

1 points

2 years ago

It would be nice for MA to get some test strips i know PA has some but we havent gotten any supply of any sort of detection device yet, as far as my research shown.

/u/newbieforever2018 📢 P 🐕≡≡==ヽ(ﾟεﾟヽ))

1 points

2 years ago

I hope that this becomes widely known so that preventable deaths can be avoided.

/u/ActionC0stanza

1 points

2 years ago

Reports are showing xylaxine present in at least 50% of the bags in the western MA area

/u/newbieforever2018 📢 P 🐕≡≡==ヽ(ﾟεﾟヽ))

1 points

2 years ago

Sheesh. That is so scary. I hope that the press is sharing stories about it.